Fresh analysis suggests that people who stop using new GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who end conventional lifestyle plans.
Findings released in a major health publication points out that while overweight people frequently drop about a fifth of their body weight while on the medication, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"People purchasing these treatments must be informed of the danger of rapid weight regain when the medication ends," cautioned researcher Dr. Susan Jebb.
This pace of recovery means a reversion to pre-treatment weight within about 18 months.
Comparing Therapies
The study, which looked at 37 of trials involving over 9,000 of patients, compared the results of these new drugs with conventional dieting.
Scientists emphasize that individuals who lose weight through dieting usually have a more gradual creep back—approximately 100 grams monthly—once they finish.
Explaining the Quick Regain
Experts propose the way of the jabs explains the heightened rebound.
The injections imitate a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of GLP-1 levels far above than normal may cause the body to generate a reduced amount of its own natural hormone, and could diminish sensitivity to its actions," said Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this GLP-1 'fix' results in hunger is no longer kept in check, making overeating a significant risk."
A Lifelong Condition?
The NHS advise the injections for people with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
Many experts say that, given the high risk of weight regain, the therapy should be considered life-long.
This view is echoed by pharmaceutical companies, who say that the findings "underscore the persistent character of excess weight," similar to managing conditions like diabetes.
Patient Accounts
People who have stopped the medication explain a sudden resurgence of hunger.
"It felt as if a switch flipping and you're instantly extremely hungry," described a patient.
This difficulty is compounded if users have not developed lasting lifestyle or habit modifications during therapy.
Growing Use
Recent estimates show that millions of adults in the UK have tried these injections in the past year, with desire being substantial.
- Use is more common among women than men.
- The middle-aged demographic shows the greatest usage rates.
- Many access the medications through private prescriptions rather than the NHS.
Finally, experts stress that while these medications are powerful tools for shedding pounds, they are not a magic cure and maintained weight loss likely depends on combined lifestyle management.
